The Control of pH of the Solution by Use of a Thermosensitive Hydrogel Containing Adenosine 5'-Triphosphate.
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A thermosensitive hydrogel prepared from poly (N-isopropylacrylamide) (P (NIPAAm) ) forms a nonpermeable dense surface layer around the gel when it was immersed abruptly in an aqueous solution at a higher temperature than its phase transition temperature 33.5°C. Thus, some matters entrapped in the gel cannot diffuse through the layer into the outer solution at higher temperatures than the transition temperature, but can do at lower temperatures. Then we investigated the applicability of the a denosine 5'-triphosphate (ATP)-entrapped P (NIPAAm) gel (ATP-Gel) to control of pH of the solution containing Zn<SUP>2+</SUP> by fluctuating of the outer solution between the two temperatures above and below the transition temperature. ATP was selected as a diffusate from the gel in consideration of some application to the Drug Delivery System (DDS). On immersing the ATP-Gel in the Zn<SUP>2+</SUP>-containing solution, the release of ATP from the ATP-Gel was confirmed by an increase in UV absorption based on the adenine ring of the ATP molecule and a simultaneous decrease in pH of the solution was observed due to the release of H<SUP>+</SUP> with the formation of ATP-Zn<SUP>2-</SUP>C binary complex. In case of the abrupt immersion of the ATP-Gel in the solution at 40°C, the pH of the solution remained almost constant, indicating the depression of the release of ATP from the ATP-Gel. It was able to regulate the decrease and constancy in the pH of the Zn<SUP>2+</SUP>-containing solution repeatedly by the alternate immersion of the ATP-Gel in the solution between 25°C and 40°C. Further, an ATP-Gel with an increased degree of crosslinking showed a more gradual decrease in the pH of the solution at 25°C.
- 公益社団法人 日本化学会の論文
公益社団法人 日本化学会 | 論文
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