Aphanamixins A–F, Acyclic Diterpenoids from the Stem Bark of Aphanamixis polystachya
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Six new acyclic diterpenoids named Aphanamixins A–F (1–6), together with two known compounds of nemoralisin and nemoralisin C, were isolated from the stem bark of Aphanamixis polystachya (<span style="font-variant: small-caps;">WALL</span>) J. N. <span style="font-variant: small-caps;">BARKER</span>. Their structures were established through a comprehensive analysis of NMR spectroscopic data and high resolution mass spectrometric data. The absolute configurations of carbon stereocenters were determined by means of auxiliary chiral α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) derivatives and circular dichroism (CD), respectively. All the new isolates were tested for their antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines and they exhibited weak cytotoxicities (IC50>10 µ<span style="font-variant: small-caps;">M</span>). Moreover, we highlighted that the six new diterpenoids characterized by acyclic skeleton was rarely seen in nature.
- 公益社団法人 日本薬学会の論文
公益社団法人 日本薬学会 | 論文
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