Immunization studies on Newcastle disease virus B<SUB>1</SUB> strain:II. Immune responsesof chickens having congenital passive immunity
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Ckickens having congenital passive immunity were examined for immune resoponse when vaccinated with the Hitchner B1 strain of Newcastle disease virus at 3 to 18 days of age through drinking water and by the intranasal route. The following results were obtained.<BR>Antibodies of hemagglutination-inhibition (HI) and neutralization were detected from 18 to 39 days of age. The resistance to challenge made up to 24 to 27 days of age varied in chickens having congenital passive immunity.<BR>2. When adiministered with vaccine through drinking water at 3 or 4 days of age, chickens showed no increase in the response of antibodies three weeks after vaccination. Only 17 to 55% of these chickens were proved to be immune against challenge. When chickens were vaccinated at 12 days of age or later, the resistance to challenge increased to 80 percent or higher. Antibodies also increased slightly in chikens vaccinated at 15 days of age.<BR>3. There was no serological response in chickens vaccinated intranasally at 3 or 4 days of age. Of the chickens, 60 to 80 percent resisted against challenge.<BR>4. There was a marked difference in resistance. to challenge between chickens administered with live vaccine and those not vaccinated but with the hemagglutination-inhibition titer.
- 公益社団法人 日本獣医師会の論文
公益社団法人 日本獣医師会 | 論文
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