A Case of Erythema Induratum Bazin Combined with Lichen Scrofulosorum Following Interferon-.ALPHA. Therapy for Virus C Hepatitis.

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The patient is a 42-year-old female. No tuberculosis is in her family and her past history.Since five years ago, indurations and ulcers have repeated on her lower legs. She was diagnosed hepatitis C four months ago, and at two months of interferon-α therapy, many small papules appeared on her arms and trunk and painful indurations recurred on her lower legs. Histopathologically, a granulomatous infiltrations of the panniculitis with caseation necrosisare seen in the specimen from the induration on the lower leg, and subepidermal small aggregatesof non-caseating granulomas from the papule on her arm. She showed a strongly positive Tuberculin reaction, but no active signs of tuberculosis could be pointed out in her systemic examination. Acid fast bacilli were not detected in the skin specimens, even by the polymerase chain reactions, but skin lesions of both indurations and papules disappeared by the oral administration of levofloxacin, 300mg/day.
日本皮膚科学会大阪地方会の論文