A Case of TEN due to Bucillamine.
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概要
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We report a case of toxic epidermal necrolysis (TEN) due to bucillamine. A 27-year-old women developed general fatigue and several small erythematous lesions on the extremities after taking oral bucillamine 300mg/day for 7 days for her rheumatoid arthritis of 11-years duration. Skin lesions exacerbated after stopping the drug, progressing into generalized erythema with blisters and erosions. Histopathological findings of a biopsy specimen taken from a blister on the forearm showed epidermal necrolysis with dermal perivascular lymphocytic infiltration. She recovered from TEN by systemic corticosteroid therapy. An in vitro lymphocyte transformation test for bucillamine was negative, but patch tests with various dilutions of bucillamine showed positive findings.
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