P21/Cip1 Expression in Response to Cutaneous Brossaging in Dogs.
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概要
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P21/Cip1 is a nucleoprotein associated with and inhibiting cyclin-CDK complex kinase activity and thereby blocking transition from G1 to S in the cell cycle. Recently, it has become clear that P21/Cip1 is im licated in the-regulation of proliferation and differentiation of keratinocytes.<BR>In this study, we showed by immunohistochemistry that the expression of P21/Cip1 protein in keratinocytes was increased after brossaging canine skin using a needle. Furthermore, the induction of P21/Cip1 was later than that of PCNA and continued until the time when PCNA was suppressed. We suggest that P21/Cip1 might regulate keratinocyte proliferation.
- 日本皮膚科学会大阪地方会の論文
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