Contact Allergy from Lanolin. The Incidence of Hypersensitivity and Clinical Features of Lanolin Dermatitis These 10 Years.:The Incidence of Hypersensitivity and Clinical Features of Lanolin Dermatitis These 10 Years

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The incidence of positive reactions in patch tests from 3 kinds of lanolin related substances was statistically studied in 4, 839 patients seen from 1982 to 1991 at our clinic. The average incidence of hypersensitivity to anhydrous lanolin was 0.6%, that to hydrogenated lanolin 1.7%, and that to 30% wool alcohols 2.0%. The incidence of positive reactions to lanolins decreased, compared with 2.0%, 3.9% and 3.2% in 1974 to 1976. 156 patients reacted to one or more substance (s).<BR>Out of 149 patients, the cause of lanolin dermatitis was confirmed as topical medicaments in 35, cosmetics in 18 and soaps or shampoos in 6. Atopic dermatitis and leg ulcer occupied 26.8% (40/149) and 9.4% (14/149) as a background disease of lanolin dermatitis. 120 patients reacted to other than lanolin related substances and 62 were positive to various fragrance materials. Among lanolin derivatives, positive incidence to acetylated lanolin was 11.3% (9/80) and to isopropyl lanolate was 7.9% (13/164). They are rather higher than those of 3 kinds of lanolin related substances.
日本皮膚科学会大阪地方会の論文