Clinical evaluation of Acyclovir for herpetic infections in the oral and maxillo-facial regions.

概要

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We used Acyclovir (ACV) in oral herpetic infections (herpetic gingivostomatitis : 12 cases, herpes aoster : 2 cases) . ACV was intravenously used 5mg/kg, two times per day, for at least five days. The clinical effectiveness of ACV was clinically and virologically compared to the ACV group and the control group (5 cases without ACV) in the patients of herpetic gingivostomatitis. There was no difference in the clinical signs between the two groups. However, there was a difference in the frequency of viral isolation between the two groups. According to viral shedding for five days after the administration, the frequency of viral isolation was 20.6% for ACV group and 47% for control group. No side effects or abnormal changes in laboratory findings appeared in any of the cases.
日本歯科薬物療法学会の論文