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Recently, the topical anesthesia with 20% Benzocaine (Hurricaine-R) have been developed in the United States of America. In this present study, 96 children (liquid type ; 45, gel type ; 51) aged over 3 years were chosen as the subject of this onset effects investigation clinically. The neuromuscular action potential of frog was evaluated in this experimental study to have been compared with 8% Lidocaine. The results were as follows. 1. In liquid type, there were effective results in 72.1% and without effect in 28.9% in the total results. 2. In gel type, the results were more remarkable than those in liquid. 96.1% were effective and only 3.9% were of no effect. 3. No side effects were found in both liquid and gel type. 4. Regarding the disappear time and recovery time of action potential between Benzocaine and Lidocaine, the onset effect of Benzocaine was short and recovery time would be inclined to be longer than that in Lidocaine. Benzocaine had an immediate effect and the long lasting time in anesthesia was obtained as compared with Lidocaine.
日本歯科薬物療法学会の論文