:Ampicillin concentration in acute experimental inflammed gingiva of rat following a single oral administration of tarampicillin

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The influences of the simple and infectious inflammations on Ampicillin (ABPC) concentration in gingiva, labial tissue in the mandible associated with incisor, of rats following a single oral administration of Tarampicillin (TAPC), 300 mg/kg, was studied. In order to form acute experimental inflammation in gingiva, 1.0% carageenin solution (0.025 ml) and Staphylococcus aureus suspension (0.025 ml, 1010 organisms/ml) were injected into the labial tissue in the mandible associated with incisor, 5 and 24 hours before the oral administration of TAPC, respectively. The pH and temperature of the inflammed gingiva were also determined. The following results were obtained: (1) Carageenin inflammed gingiva gave the highest pH, which was followed by the control. S. aureus infected gingiva gave the lowest pH. (2) Carageenin inflammed gingiva gave significantly higher temperature than the control. S. aureus infected gingiva gave approximately the same as that of carageenin inflammed gingiva. (3) The tissue concentrations of ABPC in both carageenin and S. aureus infected gin-givas were slightly lower than that of control (approximately 25% lower in AUC) . (4) The ratio of (tissue concentration) / (serum concentration) was calculated to demonstrate that both inflammed gingivas by carageenin and S. aureus gave lower values than that of control. Decreases of the ratios by carageenin and S. aureus were 40 and 22%, respectively.
日本歯科薬物療法学会の論文