Development of Piezo Micromanipulator for cell Micromanipulation

概要

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Positioning mechanisms with the resolution of micro-meter order are required for precise cell manipulation in biotechnology. Conventional hydraulic manipulators and electromagnetic ones have following two problems:(1) The performance of manipulation depends on operator's skill.(2) It is difficult to insert a capillary into elastic membrane of a cell, and the cell is sometimes destroyed. A new micro-manipulator and micro-injector for cell manipulation are introduced in this paper. These are driven by the precise positioning mechanism utilizing rapid deformations of piezoelectric elements, which have high positioning resolution. This micro-manipulator can insert a capillary into elastic membrane of a cell smoothly and seldom damage membrane, because this mechanisms uses impacts caused by rapid deformations of piezoelectric elements. This micro-injector can inject less volume per pulse than the conventional ones. Therefore these mechanisms solve previous problems. They are very simple, compact and suitable for cell manipulation and its automation.
日本哺乳動物卵子学会の論文