Studies on Mechanical Denaturation of High Polymer Solutions:VII. Relation between Mechanical Denaturation and Helical Content of Poly-L-Glutamic Acid in Aqueous Solutions

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The relation between the mechanical denaturation and the conformation of poly-L-glutamic acid (PGA) in aqueous solution was studied with optical rotatory dispersion (ORD) method. The PGA having α-helical conformation with helix content of 80-90% coagulates by shearing force in the aqueous solutions. These results agree with those of the previous reports.<BR>From the measurements of viscosity and ORD of PGA in these solutions, it is found that the helix content was found to decrease with increasing temperature from 20 to 60°C.<BR>From the IR spectra, the PGA films which were obtained by evaporating these solutions of pH4.0 at room temperature are shown to be of α-helical conformation, but the films obtained at 80°C at the same pH are shown partly of the β-structure.
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