蚕における軟化病ウイルスと細菌との混合感染の動態

概要

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Various doses of the infectious flacherie virus (IFV) were injected to gnotobiotic larvae of the silkworm in different instars. Death and arrested development were observed in the infected larvae.IFV-susceptibility in the larvae in the early stages of development was 103-106 times as high as that of larvae in later stages. Ordinary larvae fed on artificial diet or on mulberry leaves were 10-30 times more sensitive to IFV infection than gnotobiotic larvae in each instar.The susceptibility of the IFV infected larvae increased in presence of Streptococcus faecalis and Serratia marcescens. The intestine of larvae infected with IFV and these bacteria contained a large number of bacteria in the molting period. When chloramphenicol was administered to these infected larvae, the bacteria that remained at molting were removed from the intestine and the life of the infect larvae could be prolonged.The bacteria associated with higher virulence in IFV infection were endogeneous S. faecalis which is the main component of the intestinal flora of the healthy larvae compared with exogeneous S. marcescens.
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