Histochemical Studies on Brain Edema
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概要
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Brain edema is believed to occur not only in the cases of cerebral diseases, but also in others such as uremia, hepatic coma and heart failure. Although it is very important problem to study its pathogenesis even in clinical medicine, it has not come to a sufficient understanding.<BR>The studies on brain edema at the initial stage were carried out mainly from the standpoint of morphology, then extended to the physical and chemical ones, including electron microscopic study. Furthermore, histochemical method has been introduced in this field lately. In Japan also, Ambo reported some histochemical studies of brain edema concerning some enzyme activities.<BR>On the other hand, there have been many ways to produce a experimental brain edema on animal. Since Magee's report in 1957 using Alkyl Tin compounds for this purpose, many reports of pharmacological properties on these agents were followed. Thus Aldrige and Cremar found that triethyl tin compound (TET) induced mitochondrial swelling in the liver cell and inhibited its oxidative phosphorylation.<BR>We also have used TET in the experimental study of brain edema, esp. from the bio-and histochemical standpoint. Our findings, so far, are as follows;<BR>1) Water, sodium and chloride contents in brain tissue incresead, while potassium showed a only slight decrease.<BR>2) Histologically, light microscope showed few changes in superficial layer of cerebral cortex, but the perivascular and pericellular spaces were found to be dilated progressively in deeper layers, and in the white matter a prominent vacuolisation of various size was seen, resulting in sponginous appearance.<BR>3) Electron microscopy proved no apparent changes on the capillary wall, but huge cavitation between splitted lamellae of the myelin sheath.<BR>The present paper is to investigate some histochemical aspects of brain edema, comparing with the biochemical analysis.
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