Histochemical Changes in the Sciatic Nerve Following Sciatic Neurotomy in the Guinea Pig

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1) No enzyme activities for succinic dehydrogenase and DPN-diaphorase in myelin sheath of normal, degenerating and regenerating sciatic nerve could be demonstrated by histochemical methods. Non-specific esterase activity could be found in the nerve fiber but not in axons, their distribution in nerve fiber was in irregular pattern with fine positive granules.<BR>2) The myelin structure in fresh frozen sections showed circular thin threads, and this structure coincided with electron microscopic view.<BR>3) Alteration of succinic dehydrogenase and DPN-diaphorase in the proximal stump following sciatic neurotomy: Axonal swelling accompanied with a damming of succinic dehydrogenase and DPN-diaphorase at the end site of axon and increased enzyme activity in the Schwann cell were noted.<BR>4) The changes in monoamine oxidase activity in the regenerating nerve fiber in proximal stump showed a very interesting localization, during the regeneration of sciatic nerve, the mid-portion of proximal stump demonstrated strong monoamine oxidase activity in the outer surface of the axon and this may indicate the axon-Schwann cell membrane.
日本組織細胞化学会の論文