Serum Creatine Kinase and Lactate Dehydrogenase Isoenzymes in Skeletal and Cardiac Muscle Damage in the Horse
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概要
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Creatine kinase (CK) and lactate dehydrogenase (LDH) isoenzymes were determined at different time intervals in sera from racehorses with skeletal and cardiac muscle damage. In the case of the tying-up syndrome, the elevated activities of CK-MM1 and LDH5 bands were found according to the degree of clinical conditions. Two types of serum isoenzyme profile were seen in 26 cases of the serious group. In one type, the activities of MM1 and LDH5 bands increased considerably, and returned to the normal value within 7 days. Of the 26 cases, 21 (80%) were classified into this type and prognosis was favorable in them. In the other type, the activities of LDH1 and CK-MB bands were elevated in addition to the profiles mentioned above. In this type, the complication of cardiac muscle damage was considered. The recovery of these elevated profiles was slow, requiring a few weeks to take place, with relapse or muscle pain. Prognosis was generally adverse in this type. The degree of damage in skeletal and cardiac muscles was clarified precisely by the analysis of CK and LDH isoenzymes. These analyses at different time intervals were very useful for clinical application to grasp variation in clinical conditions, make prognosis roughly, establish a proper therapy, determine the efficiency of therapy, and fix the time of resumption of training. Also, the attack of relapse or chronic muscle pain in the case of the tying-up syndrome with cardiac muscle damage would be preventable by the application of CK and LDH isoenzyme profiles.
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日本ウマ科学会 | 論文
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