Pathological Observations on Equine Leukemia Complex in Japan
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概要
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The equine leukemia complex (EL) was found in 14 horses during the past 30 years (1949-1979). Patho-morphologically, it was classified into the following types according to the characteristics of tumor cells. (A) lymphosarcoma (LS) in 12 cases; lymphocytic LS (2 cases), lymphocytic and prolymphocytic LS (3 cases), lymphoblastic LS (2 cases), histiolymphoblastic LS (1 case), poorly differentiated histiocytic LS (1 case), histiocytic LS (2 cases), and histioblastic LS (1 case); (B) stem cell leukemia in 1 case; (C) myeloid leukemia in 1 case. Of the 14 horses, five were 2 to 3 years of age, six 8 to 17 years, and three of unknown age. Of the 12 horses with LS, nine suffered from the multicentric form, one from the alimentary form, and two from the solitary form. Two horses with subcutaneous tumor were observed. The organs most frequently involved in EL were the lymph nodes, which were followed by the spleen, kidneys, intestines, and liver. The heart, lungs, thymus, skeletal muscle, and skin were involved to a lesser degree. In the ultrastructure of histiocytic LS, in particular, there was a wide variation in the distribution and structure of rough surfaced endoplasmic reticulum. Large vacuoles were often found in the cytoplasm of the tumor cells. The highly polymorphic nuclei, markedly large nucleoli enlarged Golgi area, and abundant free ribosomes in these cells were indicative of high metabolic activity. No virus particles were observed in the cases examined by electron microscopy.
- 日本ウマ科学会の論文
日本ウマ科学会 | 論文
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