Effect of Intra-articular Injection of Orgotein (HM-81) on Horses

概要

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Orgotein was injected into the left or both radiocarpal joints of each of 12 healthy horses under various conditions in order to examine effect of intra-articular injection of it. In these horses general and local conditions of the radiocarpal joints injected with orgotein were observed, and blood, urine and synovial fluid test were done. Further, changes in the concentration of orgotein were examined in the synovial fluid and serum after intra-articular injection of the drug. This injection caused an increase in total protein concentration and cell count in the synovial fluid, and prevented the hyaluronic acid concentration from decreasing in this fluid. There were no changes in the other results. In the synovial fluid orgotein was initially high in concentration, but decreased at a fairly rapid rate over a 24-h period. In the serum it increased initially in concentration at a fairly rapid rate over a 4-h period and decreased gradually over a 72-h period.
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