Seasonal changes in the levels of plasma cyclic AMP and cyclic GMP.
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概要
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To investigate seasonal changes in the hormonal action and the function of autonomic nervous system, the levels of plasma cyclic AMP and cyclic GMP were examined over a year.<BR>Blood samples from the median cubital vein were collected every month (from May 1983 to February 1984) from a group of healthy adults (13 males) with a mean age of 21.5 years.<BR>1. Blood was always collected at the rising hour (A.M. 6 : 00 from April to November and A.M. 6 : 30 from December to March) in basal metabolic condition.<BR>2. Plasma cyclic AMP and cyclic GMP were measured by RIA using <SUP>125</SUP>I labelled succinyl cAMP tyrosine methyl ester (the Yamasa cyclic AMP assay kit, Yamasa Shoyu K.K.) and <SUP>125</SUP>I labelled succinyl cGMP tyrosine methyl ester (the Yamasa cyclic GMP assay kit, Yamasa Shoyu K.K.), respectively.<BR>The obtained values were individually standardized for each individual subject (a person's value of a month/a corresponding person's mean values of a year) and then were used for examination of seasonal changes.<BR>3. Plasma cyclic AMP changed significantly with a circannual rhythm; a drop in the level was found from August to September and a rise from November to January.<BR>Statistical significance (p<0.001; Student's t-test) was revealed between the highest monthly mean value and the lowest.<BR>4. Plasma cyclic GMP showed a significant seasonal change which was different from that of cAMP; a rise in the level occured from July to August.<BR>5. The ratio of cAMP and cGMP i.e., cAMP/cGMP, also changed significantly.<BR>The change of cAMP/cGMP was unique; a drop in the level was found from August to September, and rises from May to June and from November to January.<BR>Statistical significances (p<0.001; Student's t-test) were observed between the monthly mean of August and the value of June and November.
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