Experimental study on an effect of artificial CO2 baths upon tissue perfusion.

概要

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Physiological changes in subcutaneous tissue with artificial CO2 baths have been evaluated by means of mass spectrometry under the conception of tissue perfusion as the fluid matrix, consisting of blood, lymph and tissue fluid, circulates throughout the body. Mass spectrometry allows continuous evaluation of the partial pressures of each tissue gas in vivo, so that the regional flow of tissue fluid or local tissue perfusion can be measured by a desaturation method with an inactive argon gas. Tissue perfusion was evaluated on artificial CO2 baths using 7 rabbits weighing about 2 kg. Each local tissue perfusion volume was computed respectively at 16.98±8.09 (mean±standard error) ml/100 g/min, SD=9.05, p<0.05, with plain baths at a temperature of 36-37°C and at 18.23±6.09 ml/100 g/min, SD=6.81, p<0.05, with artificial CO2 baths using"BUB"-KAO1 tab. (a 50 g sodium hydrogencarbonate and succinic acid tablet) in the constant temperature bath of 20-litre. Increase in tissue perfusion volume with artificial CO2 baths was seen in 4 out of 7 cases. It is assumed that the improvement of tissue perfusion with CO2 baths serves as a favourable effect on homeostasis in association with the increased Po2 in tissue and the improved skin blood flow.
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