Mechanism of joint destruction in rapidly destructive coxopathy.

概要

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The mechanism of the joint destruction in rapidly destructive coxopathy (RDC) was studied by analyzing the bone resorption factors in joint liquid.<BR>The joint liquid revealed bone resorbing activities. Prostaglandins (PGs) were found to play a partial role in joint destruction. The values of interleukin-1β (IL -1β) of the joint liquid were higher than those with osteoarthritis. When the joint liquid was tested for proteolytic activity by zymography performed with SDS/polyacrylamide containing gelatin two gelatin-degrading activities with molecular weights of 95KDa and 57KDa were observed. Cells cultured from synovia obtained at surgery revealed a gelatinolytic activity with a molecular weight of 95KDa in the primary culture. PGs, IL-1β and gelatinase seem to act synergetically as promotion factors in the rapid destruction of the hip joint in RDC.
日本関節病学会の論文