HLA in the patients with pusturosis palmaris et plantaris and intersterno-Costo-clavicular ossification.

概要

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A deviation of any HLA antigen was looked for in a total of 32 patients with pustulosis Palmaris et plantaris and Intersterno-costo-clavicular ossification. Separated lymphocytes were tested for HLA-A, B, C and DR antigens using the microlymphocytotoxity technique (8th International Workshop Method) . Antigen frequencies were compared with 300 healthy controls.<BR>HLA-Bw39 was found in 12.5% of the patients, while this antigen occurred in only 6.5% of the controls. In two locus association the frequency of Bw51 with Aw24 was 22% in patients against 2% among controls.<BR>The frequency of Bw51 with DR2 was 18.7% against only 0.92%. Thus the frequencies of Bw51 and Bw39 antigens was significant different between the patients and controls. This high incidence of these B antigens of great interest, though the difference could not be confirmed statistically.
日本関節病学会の論文