:—An autopsy case—

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In rheumatoid arthritis, it is well known that changes of cervical spine are frequently seen by x-ray. However, little is known about how the changes occur. In the case described here, an autopsy was performed to investigate this mechanism.<BR>A 58 year-old woman had rheumatoid arthritis since 1943. Treatment with corticosteroid and gold was started and continued until death. x-ray changes appeared in 1970. Neurological findings appeared and subaxial dislocation of the C3 vertebrae was present in x-rays in 1974. In 1984 she died of a respiratory dysfunction.<BR>In synovial joints, proliferation and enlargement of synovium, infiltration of inflammatory cells, or plasma cells and lymphocytes, and pannus were present.<BR>Rheumatoid nodules were found in the vertebral bodies, discs and ligamenta. Infiltration of inflammatory cells were observed in the enthesis of ligamenta. The x-ray cahnges of cervical spine depends on these histological findings.
日本関節病学会の論文