Association between nociceptive and sympathetic nerve fibers in rat posterior longitudinal ligament.
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概要
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Nerve supply to the posterior longitudinal ligament has been the focus of considerable interest in order to gain insight into the pathogenesis of low back pain. Much attention has been paid to the sinuvertebral nerve, the meningeal branch of the vertebral nerve, which supplies proprioceptive, nociceptive and autonomic fibers back to the spinal canal. Recent developments in immunohistochemistry have enabled identification of various nerve fibers. In the present study, nociceptive and sympathetic innervations to the rat posterior longitudinal ligament were investigated through immunohistochemistry and immuno-electromicroscopy for calcitonin gene-related peptide and tyrosine hydroxylase, respectively. The posterior longitudinal ligament received two distinctive nerve networks, i.e., superficial and deeper networks. The superficial network supplied both nociceptive and sympathetic fibers of the sinuvertebral nerve origin, while the deeper network supplied the nociceptive alone. Resection of the dorsal root ganglia suggested that the former network received nociceptive fibers from the dorsal root ganglia of multiple levels, while the latter received nociceptive fibers unisegmentally. More peripherally, the superficial network was characterized by interdigitating, naked nerve endings of the presumable sympathetic and nociceptive axons. A special neuromodulatory function between the sympathetic and nociceptive axons was proposed as a possible function of the superficial network, while the deeper network was considered in pure sensory terms.
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