Evolution from semi-tRNA to tRNAs, rRNAs, snRNA and primitive mRNAs
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Prokaryotic tRNA<SUP>Trp</SUP> and tRNA<SUP>Phe</SUP> and some other tRNAs seem to well conserve primitive tRNA (proto-tRNA) commonly ancestral to all contemporary tRNAs. The 5'-and 3'-halves of the <I>E. coli</I> (EC) tRNA<SUP>Trp</SUP> and the <I>Bacillus svbtilis</I> (BSU) tRNA<SUP>Phe</SUP> were aligned with one another, resulting in a finding that proto-tRNA first emerged via duplication of ca. 38-base-long semi-tRNA which had (5') CCA (3') in its 3'-terminus. The peptidyltransferase (PT) region (bases 2469-2589) of 23S rRNA was found to be a close homologue of contemporary 5S rRNA (EC) showing a 54.4% base-match and a matching probability by chance, P<SUB>nuc</SUB>(62, 114)=0.21×10<SUP>-10</SUP>. This well coinsides with Noller <I>et al</I>'s (1992) recent experimental result that large-subunit rRNA has a PT activity. U1 snRNA and some possibly primitive mRNAs also showed significant levels of base sequence similarity, suggesting that some snRNAs and primitive mRNAs most probably emerged from tRNA-like or semi-tRNA-like primitive RNA (s).
- 日本バイオインフォマティクス学会の論文
日本バイオインフォマティクス学会 | 論文
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