Comprehensive Analysis and Prediction of Synthetic Lethality Using Subcellular Locations
スポンサーリンク
概要
- 論文の詳細を見る
The lethality of a gene is a fundamental and representative measure for understanding the function of a gene and its associated biosystems. Recently, many research groups have started focusing on the concept of synthetic lethality. The synthetic lethality between genes is defined by the combination of mutations in two genes causing cell death. Here, we confirm that synthetic lethality and cellular location have close relationships among the <I>Saccharomyces cerevisiae</I> genes. Furthermore, we attempt the prediction of candidate gene pairs with synthetic lethality. The prediction is based on the hierarchical aspect model (HAM) which learns from a data set of cellular location to estimate a likelihood value indicating the synthetic lethality between genes.
- 日本バイオインフォマティクス学会の論文
日本バイオインフォマティクス学会 | 論文
- Performance Improvement in Protein N-Myristoyl Classification by BONSAI with Insignificant Indexing Symbol
- A combined pathway to simulate CDK-dependent phosphorylation and ARF-dependent stabilization for p53 transcriptional activity
- A versatile petri net based architecture for modeling and simulation of complex biological processes
- XML documentation of biopathways and their simulations in Genomic Object Net
- Prediction of debacle points for robustness of biological pathways by using recurrent neural networks