Systematic DNA-Binding Domain Classification of Transcription Factors
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概要
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Based on the manual annotation of transcription factors stored in the TRANSFAC database, we developed a library of hidden Markov models (HMM) to represent their DNA-binding domains and used it for a comprehensive classification. The models constructed were applied on the UniProt/Swiss-Prodt database, leading to a systematic classification of further DNA-binding protein entries. The HMM library obtained can be used to classify any newly discovered transcription factor according to its DNA-binding domain and, thus, to generate hypothesesa bout its DNA-binding specificity.
- 日本バイオインフォマティクス学会の論文
日本バイオインフォマティクス学会 | 論文
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