Lung Injury and Carcinogenesis Following Transtracheal Instilation of Diesel Soot Particle to the Lung
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概要
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In order to clarify the harmful effects of diesel exhaust particles to the luug, transtracheal instillation of diesel particles (totally 10mg) into the rat's lungs were performed. For comparison activated carbon partilces and solvent were also instilled to the other group. Non-treated control was also prepared. Eighteen months to 30 months after instillation rats were killed and examined. Pathologically many epithelial hyplasias and lung tumors, including carcinoma, and leukemias were seen in diesel particle group. Statistically significant percentages of lung cancer were seen in the diesel particle group comparing with activated carbon group and solvent group. No epithelial hyperplasia or lung tumor was seen in the non-treated control group. These data mean diesel particles are harmful (especially carcinogenicity) to the rat's lung.
- 社団法人 大気環境学会の論文
社団法人 大気環境学会 | 論文
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