Relationship between the Air Pollution and Lung Cancer

概要

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Dogs are good models for studying the relation between air pollution and lung cancer. One thousand dogs with recorded life histories in Kawasaki city were autopsied. As results of histopathological studies, their degrees of lung contamination and findings of pathological changes were evaluated. The degree of lung contamination increased with age: 43.0% of the old dogs from the industrial zone had highly contaminated lungs, as opposed to only 20.6% of the dogs of the same age group from the residential zone in Kawasaki city. Emphysema observed among the dogs was of the centrilobular-type and was seen Particulary in the older dogs with highly contaminated lungs. Epithelial proliferation around the thrombotic scar caused by Dirofilaria immitis was also seen, but there was no difference as regards the zone. There were 14 lung tumor cases: 7 were benign (2 bronchial papillomas, 5 adenomas) and 7 malignant (6adenocarcinomas, 1 epidermoid carcinoma), without undifferentiated carcinomas (so-called oat cell type). There were 3 cases of multiple carcinoma. All 7 malignant cases located in midzonal and in the peripheral area of the lungs. Four cases were from the industrial zone, from the commercial zone, and 2 from the residential zone; all dogs were older than age of 8. Therefore, air pollution is recognized to give a strong influence on the incidence of both lung contamination and lung cancer.
社団法人大気環境学会の論文