Metabolic Pathway of Nitric Oxide

概要

論文の詳細を見る
Metabolic pathway of inhaled NO was investigated with 15NO in rats. After the 15NO exposure with exposure apparatus shown in Fig. 1, contents of the 15N (atom % excess) in blood, red cell, serum, each organ tissue (perfused with saline solution) and urine were estimated. Contents of the 15N in the samples of blood, serum, red cell and urine were relatively high and those of lung, trachea, liver, kidney and muscle were low (Table 2 and Fig. 2). Blood samples in an hour after 15NO combined blood injection from rats were analyzed. Greater part of the 15N in the serum were in fraction of the ultrafiltrate and contents of NO-3 in the serum werer emarkably elevated compared with those of the control rats (Table 4). In 24 hours and 48 hours after 15NO combined blood injection, the urine samples were collected. Most of the 15N in the urine was found within 24 hours (Table 5). Red cells from the 15NO exposed rats were washed (mixrd and incubated) with the saline solution or serum from normal untreated rats. The 15N in the red cells was easily extracted with the solution or the serum, but the 15N in serum from the exposed animal was scarcely transfered to red cells (Table 3). Through the experiments, we presumed that inhaled NO primarily reacted with hemoglobin and was changed to NO-2/NO-3 in red cells, then the metabolites were removed to serum and a part of those reacted with tissues and the other greater part was excreted in urine in the form of NO-3 (Fig. 4).
社団法人大気環境学会の論文

Metabolic Pathway of Nitric Oxide

スポンサーリンク

概要

社団法人大気環境学会 | 論文

スポンサーリンク

Metabolic Pathway of Nitric Oxide

スポンサーリンク

概要

社団法人 大気環境学会 | 論文

スポンサーリンク

社団法人大気環境学会 | 論文