CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EAST KALIMANTAN AND WEST IRIAN II. ADDITIONAL CASES AND REVIEW OF THE PROBLEMS

概要

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1) Two cases of falciparum malaria infected at Sangkurilang, East Kalimantan and a case infected at Kimi Bay, West Irian were found to be chloroquine RI resistant. 2) All the 3 patients were given 1, 800 mg of chloroquine base (27, 31 and 27 mg per kg of body weight) in four days. The drug was not vomited, and its absorption was confirmed by quatitative study of the blood and urine for chloroquine. The reinfection was excluded when recrudescence occurred. 3) The in vitro chloroquine-sensitivity test was made and the 50 percent maturation inhibition concentration of chloroquine against the three isolates and a chloroquine-sensitive Sri Lanka strain was 0.90, 0.55, 0.44 and 0.14 nM/ml, respectively. 4) 34 cases of malaria (29 vivax and 5 falciparum) were imported from Kalimantan, West Irian, Papua and New Guinea during the past 10 years. Falciparum malaria was seen for the first time in 1974 and all the 5 cases turned out to be chloroquine-resistant. It is concluded that chloroquine resistant falciparum malaria is prevalent in East Kalimantan and West Irian.
日本熱帯医学会の論文