An Outbreak of Aseptic Meningitis in Okinawa in 1993.

概要

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In the summer of 1993, an epidemic of aseptic meningitis had broken out in Okinawa island, the southernmost area of Japan. It started in June (or probably in May), reached a peak early in July and subsided in August. A total of 216 specimens (cerebrospinal fluids, throat swabs and sera) was collected from the patients with aseptic meningitis and viruses were recovered from 83 specimens (38.4%). Five isolates randomly selected were examined for the identification of the virus. The virus was identified as echovirus type 30 (echo-30) by plaque reduction neutralization test using enterovirus antiserum pools and monospecific antiserum. Large-plaque and small-plaque phenotypes of echo-30 were isolated. The two were neutralized by anti-echo-30 sera. For the plaque assay of echo-30 in RD-18S cells, the use of tragacanth gum for the overlay medium could reduce the incubation period to 25-30 hr.
日本熱帯医学会の論文