Malaria Serology as an Alternative to Parasite Detection in a Highly Endemic Amazonian Community.

概要

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The Indian colony under study is located in relatively inaccessible part of the Amazonian jungle, restricting frequent visits. Malaria survey in such a community requires methods which would yield reliable results even from a single visit. Malaria was regarded as a minor disease by the inhabitants who appeared to be free from malaria. The reported incidence was very low, and in fact, no parasitemia was detected in the blood smears of a group of inhabitants obtained through our short visit. But on the contrary, an avidin biotin peroxidase complexed enzyme-linked immunosorbent assay (ABC-ELISA) revealed a 100% prevalence of malaria antibodies in the population. Therefore, serological studies which can obtain the <I>period prevalence</I> are useful for the assessment of malaria situation in the highly endemic community which is not readily accessible, or whose populations seem to have acquired a certain degree of immunity depressing parasitemia to submicroscopic levels.
日本熱帯医学会の論文