Defect of post-triggering natural killer cell mediated cytolytic activity by synthetic HIV analogue peptides.

概要

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Three kinds of peptides termed ABJ917, ABJ918 and ABJ919 were synthesized and tested their capability of inhibition of Natural Killer (NK) cell mediated cytotoxicity. ABJ917, which is conserved among various retroviral transmembrane envelope proteins inhibited NK activities of the peripheral blood lymphocytes (PBLs) of both asymptomatic carriers and normal controls. ABJ918 or ABJ919 which correspond to this conserved region also inhibited NK activities. To know the mechanism of inhibition of NK cells by these synthetic peptides, conjugate formation assay and triggering assays were then performed. ABJ917 which inhibited overall NK cytotoxicity did inhibit neither NK and target tumor cell binding nor NK cell triggering by target K562 tumor cells. These results show that the inhibition of NK cytotoxic activity by synthetic HIV peptide is caused in the stage of post-triggering. Peripheral blood CD4<SUP>+</SUP> cell rate of the asymptomatic carriers of HIV was almost 0% when we obtained enough NK activities and these carriers were still quite healthy. Taken together, the immunosuppression of AIDS patients is thought to be caused at least partly from some defects of post-triggering lytic activity of NK cells by HIV transmembrane peptides.
日本熱帯医学会の論文