マラリア患者の血液生化学的所見

概要

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Biochemical parameters of blood were analyzed statistically in the same way as in the groups of malaria patients mentioned in the accompanying paper. The parameters which directly or indirectly reflect intravascular hemolysis, i.e., lactic dehydrogenase (LDH), total bilirubin (TBil), blood urea nitrogen (BUN), creatinine (Crt), serum alanine aminotransferase (SGPT) and serum asparate aminotransferase (SGOT) were elevated in malaria patients infected by P. falciparum (P.f.) significantly more than in malaria patients infected by P. vivax (P.v.) or P. ovale (P.o.). The differences in the biochemical parameters of the last two groups were not significant. The total protein (Tp) levels also showed the same order of decrease. Cholesterol (Chol) was decreased equally in malaria patients irrespective of the infecting parasite species. The maximum values of LDH (15, 290 u/l), TBil (42.3 mg/dl), BUN (204 mg/dl), Creat (16.9 mg/dl), SGPT (455 u/l), and SGOT (653 u/l) and the lowest figures of Chol (50 mg/dl) and Tp (3.2 g/dl) in Pf malaria indicate the seriousness of this infection. The same parameters in vivax malaria are LDH (5, 140), TBil (6.4), BUN (26), Creat (1.9), SGPT (260), SGOT (180), Chol (51) and Tp (5.2). The early treatment of falciparum malaria, within 5 days of the onset of illness, is emphasized to avoid serious complications.
日本熱帯医学会の論文