Plasmodium berghei and Yoelii : A correlation of survival periods and immunological parameters in BALB/c mice.

概要

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After inoculation with <I>Plasmodium berghei</I> NK65, BALB/c nu/nu mice survived longer than normal BALB/c mice. No such difference was found after infection with <I>Plasmodium yoelii</I> 17X. The difference in survival periods was not due to a difference in parasitemia level; studies of several immunological parameters revealed that the mice that survived longer showed an increased ability to generate interleukin-2 and cytotoxic T lymphocytes from their spleen cells. The survival period had no relationship with the amount of anti-malarial antibodies nor the formation of immune complexes. T cell functions were generally decreased and natural killer cell activity was raised in all mice regardless of their different survival periods.
日本熱帯医学会の論文