Schistosome infections among Japanese during long stays in endemic areas. Evaluation of serological diagnosis, eosinophilia and treatment with praziquantel.

概要

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Serological diagnosis using micro-ELISA was conducted for 152 Japanese who stayed for a long period in areas where schistosomiasis was endemic, and 7 cases were detected. Including these 7 cases, 9 cases were determined as schistosomiasis (3 of schistosomiasis mansoni, 2 of schistosomiasis haematobia and 4 of schistosomiasis mansoni or haematobia) and all of them were treated (7 with praziquantel, 1 with metrifonate and 1 with niridazole). By the observation of antibody titers of the cases after treatment confirmed that the antibody gradually declined and that all the cases examined became negative by 20 months after treatment. In 152 subjects examined, there were 24 cases with eosinophilia. Out of 24, 7 were cases of schistosomiasis. Among these 7 cases, 2 had noticeable eosinophilia at more than 30% of total leukocyte count. After treatment, the eosinophil count decreased and was normalized earlier than serum antibody titer. After people have stayed in endemic area for a long period, examinations for schistosome is necessary. For early diagnosis, the serological diagnosis using micro-ELISA is effective, and treatment with praziquantel at an early stage is recommended. It was suggested that results of micro-ELISA and eosinophil count were healpful in evaluating therapeutic effect.
日本熱帯医学会の論文