Phagocytic Function of Polymorphonuclear Leukocytes of Patients with Head and Neck Tumor Treated by Operation Therapy.

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The phagocytic function of polymorphonuclear leukocytes of patients with head and neck tumor treated by operation therapy was examined using the phagocytic plaque method. S. aureus, P. aeruginosa and E. coli, major pathogens of post-operative infection, were used for the research. It was found that increase in the phagocytic function of polymorphonuclear leukocytes was larger when the number of WBC was larger and operation time was longer. In addition, the phagocytic function of polymorphonuclear leukocytes for S. aureus showed higher increase than that for P. aeruginosa and E. coli in some patients with tongue carcinoma treated by operation therapy consisting of tumor resection, neck dissection and reconstruction using free rectus abdominis myocutaneous flap or pectoralis major myocutaneous flap. In patients with oropharygeal carcinoma treated by operation therapy consisting of tumor resection, neck dissection and reconstruction using free jejunal flap, the phagocytic function of polymorphonuclear leukocytes for E. coli showed higher increase than that for S. aureus and P. aeruginosa. It was concluded that this method is useful for empirical therapy for post-operative infection.
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