ENDOSCOPIC NASAL FINDINGS AFTER ADMINISTRATION OF RXM(ROXITHROMYCIN)

概要

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In the past, when evaluating the efficacy of sinusitis medicine for the treatment it was necessary to rely on patients subjective evaluations in such areas as condition of mucous membranes, status and volume of nasal discharge, nasal obstruction, headaches etc. However, because such evaluations are not rigorous and leave room for uncertainty, we are using an endoscope to observe the condition of the ostium and the amount of nasal discharge. We administered RXOM to sinusitis patients and observed its effect on the nasal cavity of two contrasting groups of patients-groups I that did not undergo surgery and groups II that did undergo surgery and afterwards complained of a recurrence of inflammation. Both groups received two daily dosages of 150 mg RXM for four weeks. We used a Hopkins endoscope attached to a VTR system which made video prints from which we could make evaluations. The results was that we observed an improvement in the nature of the discharge in 70% of the patients in group I, 80% of the patients in group II, for an average of 75%. The amount was 100% in group I, 90% in group II for an overall average of 95%. As a result of observing the video prints, we can conclude that the effect of RXM on sinusitis is to cause nasal discharge to change from pus to mucus and to decrease in volume.
耳鼻咽喉科展望会の論文