On the significance of the histological studies of hard tissue.

概要

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Osteological research in otolaryngology is very important because of some organs in the ear, nose and throat are incased with bone and cartilage. One of the characteristics of hard tissue is to be mineralized deposited hydroxyapatite and the experimental methods of hard tissue different compare to that of soft tissue.<BR>The causes of pathological demineralization are that some lesions including inflammatory, cystic and tumorous diseases of soft tissue extend to surrounding bone.<BR>We can observe various vital reactions in the bone removal from patients with chronic otitis media, uremia, cancer and cystic deseasses of nose and paranasal sinuses by special methods. Non-deminaralized materials have to be used to observe demineralization, osteoid and calcification front.<BR>The otic capsule, tibia and femur from rats with hypervitaminosis A and controls is used in experiment. Methods used in our research are autoradiographic, colchicine, histochemical, radiomicrography and electron probe X-ray microanalytical technique. The each experimental methods are described and the results from these techniqre are discussed.<BR>It is explained that avaiable methods are chosen to carry out the in osteology because purpose of histological studies in basic otolaryngology is different from that in clinic.
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