The Mutagenic Potential of the Human Intestinal Flagellate, Giardia Iamblia P1 Tested on Experimental Mice.
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The sample of the human intestinal parasitic flagellate, Giardia lamblia P1 (P1 Tr1) and the supernatant fluid (Su Tr2) and the precipitate suspended in saline (SSP Tr3) of the centrifuged autoclaved G. lamblia culture were intraperitoneally injected individually to separate sets of mice at the rate of 1ml per 100g body weight against sterile TYI medium (TYI Co1) and nomal saline (Sa Co2) injected controls which yielded maximum cytogenetic effects with respect to bone marrow chromosome aberration frequency, micronucleated erythrocytes and sperm head abnormality tests in supernatant fluid treated sample (Su Tr2) and followed in descending order by the treatment of G. lamblia P1 sample (P1 Tr1) and saline suspended precipitate sample (SSP Tr3). At 24 hr after treatment the net increase in frequency of effect in three different samples of G. lamblia P1 treated series over respective controls was 17.75%, 8.50% and 5.75% respectively for bone marrow chromosome aberration; 0.83%, 0.61% and 0.40% respectively for MNT and 3.15%, 2.00% and 1.10% respectively for sperm head abnormality. Further, the frequency of bone marrow chromsome aberration for the treatment of G. lamblia P1 sample (P1 Tr1) was also found higher by 2.5% at 3 hr and 12.5% on 7 days over control. On 7 days after treatment it was also higher by 0.83% for MNT and 2.85% for sperm head abnormality. Thus the mutagenic potential of different samples of G. lamblia P1 in treated mice was proved by more than one test adding a new evidence to the field of living mutagenesis.
- 財団法人 日本メンデル協会の論文
財団法人 日本メンデル協会 | 論文
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