Novel A-Seco-Rearranged Lanostane Triterpenoids from Abies sachalinensis.
スポンサーリンク
概要
- 論文の詳細を見る
From the needles of Abies sachalinensis, novel rearranged lanostane type triterpenes, 1-4, were isolated along with a known triterpene (5). The structures of the new compounds, 1-4, were elucidated to be 3, 4-seco-8-(14→13R)abeo-17, 13-friedo-9β-lanosta-4(28), 7, 14(30), 22Z, 24-pentaen-26, 23-olide-3-oic acid, methyl 3, 4-seco-8-(14→13R)abeo-17, 13-friedo-9β-lanosta-4(28), 7, 14(30), 22Z, 24-penten-26, 23-olide-3-oate, 3, 4-seco-8(14→13R)abeo-17, 13-friedo-9β-lanosta-4(28), 7, 14, 22Z, 24-pentaene-26, 23-olide-3-oic acid and methyl 3, 4-seco-8(14→13R)abeo-17, 13-friedo-9β-lanosta-4(28), 7, 14, 22Z, 24-pentaene-26, 23-olide-3-oate, respectively, by means of spectral experiments, especially two dimensional NMR spectroscopy, such as <SUP>1</SUP>H-detected multiple quantum coherence (HMQC), <SUP>1</SUP>H-detected heteronuclear multiple bond connectivity (HMBC) and <SUP>1</SUP>H-<SUP>1</SUP>H-correlation spectroscopy (COSY) experiments. These new compounds have novel structures containing A-seco, rearranged spiro structure and a γ-lactone conjugated with a diene. Some of these compounds showed potent antibacterial activity against gram positive bacteria.
- 社団法人 日本薬学会の論文
社団法人 日本薬学会 | 論文
- Bioactive Constituents from Chinese Natural Medicines. XXXVI. Four New Acylated Phenylethanoid Oligoglycosides, Kankanosides J1, J2, K1, and K2, from Stems of Cistanche tubulosa
- Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages
- Medicinal Flowers. XXX. Eight New Glycosides, Everlastosides F—M, from the Flowers of Helichrysum arenarium
- Triterpenoid Saponins from the Stem Bark of Acanthopanax brachypus HARMS
- Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate–2,2′-Bipyridyl