Effects of Low Power Laser Irradiation on the Mineralization of Tooth Germ in Mice:Third Report: Sensitive Stage for He-Ne Laser Irradiation

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The effect of low power laser (He-Ne laser) irradiation on the mineralization and alkaline phosphatase (ALP) activity in the tooth germ was examined. Mandibular first molars from 17-day-old mouse embryos were cultured with or without low power laser irradiation (the irradiation time was 5 minutes per day). During 7-day cultivation, ALP activity and calcium content in the tooth germ increased developmentally and formations to predentin, dentin and enamel were observed histologically. In tooth germ cultured with 7 irradiations for 7 days, both ALP activity and calcium content were significantly decreased and formations to predentin, dentin and enamel were inhibited. Similar results were observed in tooth germ cultured for 7 days with 3 irradiations at day-0, 1 and 2. However, in tooth germ cultured for 7 days with 3 irradiations at day-4, 5 and 6, the inhibitory effects of irradiation were not observed. These results suggest that He-Ne laser irradiation suppress tooth formation and mineralization at an early developmental stage.
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