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Photodynamic therapy (PDT) enables selective treatment of tumor tissue, by combining the use of a photosensitizer, which is specifically taken up by tumor tissue and newly formed blood vessels, and induces cytocidal effects by highly active oxygen created by laser excitation, without damaging surrounding normal tissue.<BR>PDT holds hope for elderly patients and patients at high risk, because PDT preserves organ function and is less invasive than surgery.<BR>The first generation of tumor photosensitizers was a porfimer sodium (Photofrin<SUP>®</SUP>), and the second generation includes talaporfin sodium (Laserphyrin<SUP>®</SUP>) and verteporfin (Visudyne<SUP>®</SUP>). These procedures are all recognized and reimbursed by the health insurance system of Japan.<BR>We performed preclinical experiments on PDT and photodynamic diagnosis (PDD) using Laserphyrin. Microscopically, scat tered fluorescence from Laserphyrin in tumor tissue was observed in a fresh malignant tumor specimen obtained 2 hours af ter injection, and the treatment effect of PDT using Laserphyrin was recognized in mouse tumors which had received trans planted human squamous cell carcinoma cells.<BR>We subsequently applied Laserphyrin in clinical cases and report the results in a case of tongue cancer. Good results were obtained with both PDD and PDT.
- 日本レーザー歯学会の論文