Non-platinum Gemcitabine-based Combination Chemotherapy

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Purpose. To evaluate the role of non-platinum, gemcitabine-based combination chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC). Method. Clinical trials of gemcitabine plus vinorelbine and gemcitabine plus docetaxel which were published in peer-review journals were reviewed in terms of efficacy and toxicity. Results. A phase III trial comparing gemcitabine plus vinorelbine with cisplatin -based regimens demonstrated a non-significant slight survival disadvantage with gemcitabine plus vinorelbine. Global QoL is not improved with gemcitabine plus vinorelbine, although it is less toxic than cisplatin-based regimens.A randomized trial comparing docetaxel plus gemcitabine with cispaltin plus docetaxel demonstrated similar response rate, time to tumor progression, overall survival, and two-year survival rate. Conclusion. Gemcitabine-based two drug combination is active in patients with advanced NSCLC with less gastrointestinal toxicity than standard cisplatin-based chemotherapy. Non-platinum gemcitabine-based chemotherapy could be a treatment option in patients with advanced NSCLC.
特定非営利活動法人日本肺癌学会の論文