TTF-1 Immunostaining in the Diagnosis of Gastric Metastasis From Lung Adenocarcinoma.

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Background. Although gastric metastases from lung cancer are considered to be uncommon, thedistinction of a primary gastric carcinoma from a metastatic lesion of lung cancer is often difficult because of overlappingpathologic features. Recently the antibody to thyroid transcription factor-1 (TTF-1) has been shown to be a fairlyspecific marker for lung cancer. We report two cases of gastric metastasis from lung adenocarcinoma with positive immunostaningwith TTF-1. Case. Case 1 was a 56-year-old woman who was referred to our hospital with an abnormalshadow on a chest X-ray film. The tumor was diagnosed as adenocarcinoma (c T1N0M0 stage IA). Nine months aftercurative resection, she developed epigastralgia, and gastrointestinal endoscopy was performed. Case 2 was a 52-yearoldman referred to our hospital with malignant pleural effusion. The clinical stage was IIIB (c T4N2M0). After a secondsystemic course of chemotherapy with carboplatin and paclitaxel, he complained of epigastric discomfort. Gastrointestinalendoscopy was performed. The histological specimens of both cases were immunostained with a monoclonal antibodyto TTF-1. Conclusion. Two cases of lung adenocarcinoma with metastasis to the stomach are reported, in each ofwhich immunostaning for TTF-1 was useful in obtaining an accurate diagnosis.
特定非営利活動法人日本肺癌学会の論文