Radiographic Characteristics of Early Stage of Non-mucus Producing Peripheral Lung Adenocarcinoma. With Special Reference to the Stromal Elastotic Framework of the Tumor.

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Objective: The radiographic features of early type non-mucus producing peripheral lung adenocarcinoma should be clarified based on the characteristic stromal elastotic framework formation of the tumor. Methods: Forty-four patients of early type non-mucus producing peripheral lung adenocarcinoma with preserved stromal elastotic framework (type 1) were studied with regard to the radiographic signs, including thin-section CT findings in 9 cases, making a comparison with the characteristic histology. Results: The plain radiographs showed that localized hazy shadows had vascular convergence, frequently with air bronchogram sign. The radiographic course showed that the nodule gradually increased in density without enlarging. In 9 patients in whom thin-section plain CT was performed, the nodule basically showed a localized distinctly bordered ground glass opacity (GGO) in which the vascular margin is preserved and close to the neighbor ones. The air bronchogram reflected the dilated air space of the alveolar duct. Regional increased density is seen due to the alveolar collapse on the pleural side. Coclusion: These radiographic features correlated well with the histologic characteristics of gradual contraction of alveolar walls lined by tumor cells forming an elastotic thick tumor stroma without invasion.
特定非営利活動法人日本肺癌学会の論文