Hiccups Induced by Systemic Chemotherapy for Lung Cancer.

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Object: We studied hiccups observed during systemic chemotherapy for lung cancer and prophylactic antiemetic therapy using corticosteroids and 5-HT3 receptor antagonists. Methods: Eighty-four patients who received chemotherapy for primary lung cancer in 1999 were included in these retrospective examinations from medical and nursing records. They consisted of 66 men and 18 women and ranged in age from 35 to 76 years (mean 62.5). A total of 181 courses of chemotherapy were performed: in all, 146 cisplatin-based regimen courses, 32 carboplatin-based and 3 others. Results: Hiccups were observed in 23 patients (37 courses) all of whom were male. They began at just a few hours to three days after injection of anti-cancer drugs and lasted for one to five days. Hiccups were observed in 20.5% of cisplatin-based chemotherapy courses and in 21.9% of carboplatin-based courses. There was no difference in the frequency of occurrence of hiccups between two groups (cisplatin-based vs carboplatin-based). Conclusion: It was suggested that occurrence of hiccups may be caused by interactions among anti-cancer drugs, corticosteroids and 5-HT3 receptor antagonists.
特定非営利活動法人日本肺癌学会の論文