Histopathological and Immunohistochemical Analysis of 6 Cases of Solitary Fibrous Tumor of the Pleura.

概要

論文の詳細を見る
We examined histopathological features as well as immunohistochemical features of 6 cases of solitary fibrous tumor of the pleura. Three of six patients were men and the others were women. The ages ranged from 49 to 67 and the mean was 58 years old. The resected tumors measured 1. 5-20cm (mean: 8.3cm) in the greatest dimension, and 4 cases were attached to the visceral pleura by a pedicle and 2 cases were located in the parietal pleura. Grossly, the tumor was encapsulated and the cut surface was firm, gray-white in color. Microscopically, spindle cells were arranged haphazardly in accordance with a "patternless pattern". Immunohistochemically spindle cells expressed CD34 and vimentin, and on the contrary, keratin was negative. In each of the cases, some tumor cells expressed neurofilament, S-100 or α-SMA, which indicated differentiation to neural cell, nerve sheath cell or smooth muscle cell, and in addition, bc1-2 was strongly expressed in all cases.
特定非営利活動法人日本肺癌学会の論文