A Case of Muconodular Adenocarcinoma of the Lung, Showing Ultrastructural Features of Oncocytes.

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A 65-year-old male admitted to our hospital for evaluation of an abnormal shadow on chest roentgenogram. Chest X-ray and CT scans revealed a 2.8×2.2cm sharply circumscribed tumor in the right middle lobe. The diagnosis of papillary adenocarcinoma was obtained by transbronchial biopsy and right middle lobectomy was performed. The resected tumor showed a cystic appearance and consisted of copious extracellular mucus and small clusters of cancer cells suspended in the mucus. Therefore it was finally diagnosed as muconodular adenocarcinoma. It was suggested that the tumor showed differentiation to bronchial gland because ultrastructurally most cancer cells had features of oncocytes characterized by numerous swollen mitochondria. Although the preoperative diagnosis of muconodular adenocarcinoma was difficult due to scanty cellular component, small foci of papillary adenocarcinoma found in the central site of tumor were recognized in the biopsy specimen of the present case.
特定非営利活動法人日本肺癌学会の論文